About

Hello and welcome there !

I am a first year PhD Candidate at the Kavli Institute at NTNU, Trondheim, Norway.

I am a fellow of the Innovative Training Network No 765549 M-GATE receiving funding from the EU.

👩‍🔬 You can read more about my research here 🧠

About the image used as background: this is a coronal slice of the CA1 region of the hippocampus of a mouse brain. Image was obtained with a confocal microscope at magnitude x20. Blue = DAPI; Green = GCaMP6f; Red = mcherry-C1V1

Research

I am highly interested by how our memory works!

In mammals, the hippocampus is one of the main regions implicated in the formation of our episodic memory , memory associated with a context: where was I? With whom? When?

The hippocampus is not the only region that plays a major role in the formation and consolidation of our memories, as it is ultra-connected to several cortical structures like the entorhinal cortex, the anterior cingulate cortex and the prefrontal cortex. How all these regions interact is still unclear, however recent technological advances over the last decade are helping to draw an image of the contribution of each structure during memory formation, consolidation and retrieval.

My thesis project is focused on the role of the anterior cingulate cortex in objet memory consolidation, using mice. I am using 1Photon miniscopes, directly fixed onto the animal’s head and enabling the visualization of the neuronal activity using calcium imaging. Using miniscopes is optimal to track the same subset of cells over a long period of time, thus making it adequate to study how are the neuronal dynamics evolving - and memory ! - as time goes by.

During my master’s thesis, I worked on a project focused on the hippocampus and the role of place cells. Place cells are known to fire action potentials in specific places, providing the animal with a cognitive map of its environment (coming back to the “where was I?” feature of the episodic memory). But do place cells also guide and drive navigational behaviour? We investigated this using an all-optical set up, combining simultaneous calcium imaging and optogenetic in mice performing a navigation task in a virtual-reality environment.

For more details on the place cells stimulation project:

Robinson N, Descamps L, Russell L, Schmidt-Hieber C, Hausser M; All-optical manipulation of place cells drives spatially associated behaviour, 604.12 / HHH44; SFN18 meeting, poster presentation, see SFN18 online meeting planner

Robinson N, Descamps L, Russell L, Schmidt-Hieber C, Hausser M; All-optical manipulation of place cells during spatial navigation; F087; FENS2018 meeting, poster presentation, see FENS18 online scientific program

Publications

Posters

Descamps L, Kentros C: Calcium imaging of long-term memory traces in Anterior Cingulate Cortex; NRSN PhD conference 2018. Poster and Blitz presentation

Robinson N, Descamps L, Russell L, Schmidt-Hieber C, Hausser M: All-optical manipulation of place cells drives spatially associated behaviour; 604.12 / HHH44; SFN18 meeting, see SFN18 online meeting planner

Robinson N, Descamps L, Russell L, Schmidt-Hieber C, Hausser M: All-optical manipulation of place cells during spatial navigation; F087; FENS2018 meeting, see FENS18 online scientific program

Cv

Research Experience

July 2018 - Present : PhD Candidate, Kentros Group, NTNU, Norway

October 2017 - July 2018 : Research Assistant, Hausser lab, UCL, United-Kingdom

September 2016 - September 2017 : Master student, Hausser lab, UCL, United-Kingdom

Education

PhD in Neuroscience - In Progress, NTNU, Norway

MSc Neuroscience, UCL, United-Kingdom

BSc Life Sciences, Majors in Neuroscience and Animal Physiology, Université de Montpellier, France

Technical Skills

In vivo Calcium imaging (1Photon scope nVista/Inscopix, freely-behaving animals) + in vivo simultaneous Calcium Imaging and Optogenetic (2Photon scope, head-fixed animals)

Stereotaxic surgeries (viral injections, optical access to cortical regions (windows) and subcorticals (prism implant, cortical aspiration))

Histology (vibratome, cryostat)

Notions in Python

Contact

Want to reach out ? You can shoot me an email at lucie.descamps[@]ntnu.no, or find me on Twitter 🐤

Français